A novel trivalent non-Fc anti-CD3 Collabody preferentially induces Th1 cell apoptosis in vitro and long-lasting remission in recent-onset diabetic NOD mice

A novel trivalent non-Fc anti-CD3 Collabody preferentially induces Th1 cell apoptosis in vitro and long-lasting remission in recent-onset diabetic NOD mice

Specific anti-CD3 treatment is deemed to be a promising therapy for allograft rejection and type 1 diabetes (T1D). Fc receptor (FcR) reduced-binding antibodies, by avoiding adverse effects of Fc and FcR interaction, have good therapeutic potential. We generated a trivalent anti-mouse-CD3 Collabody,...

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Bibliographic Details
Main Authors: Chuan-Chuan Huang, Hsiang-Hsuan Sung, Hsiu-Chuan Li, Shi-Chuen Miaw, John T. Kung, Min-Yuan Chou, Betty A. Wu-Hsieh
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
CD3
Collabody
trivalent antibody
type 1 diabetes
Th1
Treg
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1201853/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1201853/full

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