Truncated O-Glycan-Bearing MUC16 Enhances Pancreatic Cancer Cells Aggressiveness via α4β1 Integrin Complexes and FAK Signaling

Truncated O-Glycan-Bearing MUC16 Enhances Pancreatic Cancer Cells Aggressiveness via α4β1 Integrin Complexes and FAK Signaling

Elevated levels of Mucin-16 (MUC16) in conjunction with a high expression of truncated O-glycans is implicated in playing crucial roles in the malignancy of pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms by which such aberrant glycoforms present on MUC16 itself promote an increased...

Full description

Bibliographic Details
Main Authors: Christabelle Rajesh, Satish Sagar, Ashok Kumar Rathinavel, Divya Thomas Chemparathy, Xianlu Laura Peng, Jen Jen Yeh, Michael A. Hollingsworth, Prakash Radhakrishnan
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
MUC16
integrins
FAK
migration
pancreatic cancer
Online Access:https://www.mdpi.com/1422-0067/23/10/5459

Internet

https://www.mdpi.com/1422-0067/23/10/5459

Similar Items