Characterization of dedifferentiating human mature adipocytes from the visceral and subcutaneous fat compartments: fibroblast-activation protein alpha and dipeptidyl peptidase 4 as major components of matrix remodeling.

Characterization of dedifferentiating human mature adipocytes from the visceral and subcutaneous fat compartments: fibroblast-activation protein alpha and dipeptidyl peptidase 4 as major components of matrix remodeling.

Mature adipocytes can reverse their phenotype to become fibroblast-like cells. This is achieved by ceiling culture and the resulting cells, called dedifferentiated fat (DFAT) cells, are multipotent. Beyond the potential value of these cells for regenerative medicine, the dedifferentiation process it...

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Bibliographic Details
Main Authors: Julie Lessard, Mélissa Pelletier, Laurent Biertho, Simon Biron, Simon Marceau, Frédéric-Simon Hould, Stéfane Lebel, Fady Moustarah, Odette Lescelleur, Picard Marceau, André Tchernof
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4376729?pdf=render

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http://europepmc.org/articles/PMC4376729?pdf=render

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