Disturbed brain energy metabolism in a rodent model of DYT-TOR1A dystonia

Disturbed brain energy metabolism in a rodent model of DYT-TOR1A dystonia

DYT-TOR1A (DYT1) dystonia, characterized by reduced penetrance and suspected environmental triggers, is explored using a “second hit” DYT-TOR1A rat model. We aim to investigate the biological mechanisms driving the conversion into a dystonic phenotype, focusing on the striatum's role in dystoni...

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Bibliographic Details
Main Authors: Susanne Knorr, Lisa Rauschenberger, Muthuraman Muthuraman, Rhonda McFleder, Thomas Ott, Kathrin Grundmann-Hauser, Takahiro Higuchi, Jens Volkmann, Chi Wang Ip
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Neurobiology of Disease
Subjects:
Dystonia
DYT-TOR1A
Sciatic nerve crush injury
Brain energy metabolism
Fatty acid β-oxidation
Glucose
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124000615

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http://www.sciencedirect.com/science/article/pii/S0969996124000615

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