Total Synthesis, Cytotoxic Effects of Damnacanthal, Nordamnacanthal and Related Anthraquinone Analogues

Total Synthesis, Cytotoxic Effects of Damnacanthal, Nordamnacanthal and Related Anthraquinone Analogues

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Naturally occurring anthraquinones, damnacanthal (1) and nordamnacanthal (2) were synthesized with modified reaction steps and investigated for their cytotoxicity against the MCF-7 and K-562 cancer cell lines, respectively. Intermediate analogues 2-bromomethyl-1,3-dimethoxyanthraquinone (5, IC50 = 5...

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Bibliographic Details
Main Authors: Kong Mun Lo, Aurangzeb Hasan, Seema Zareen, Wan Yong Ho, Swee Keong Yeap, Muhammad Nadeem Akhtar, Noorjahan Banu Alitheen
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Molecules
Subjects:
Anthraquinone
damnacanthal
nordamnacanthal
MCF-7
K-562
cytotoxic effects
Online Access:http://www.mdpi.com/1420-3049/18/8/10042

Internet

http://www.mdpi.com/1420-3049/18/8/10042

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