Design and Synthesis of Novel Aminoindazole-pyrrolo[2,3-<i>b</i>]pyridine Inhibitors of IKKα That Selectively Perturb Cellular Non-Canonical NF-κB Signalling

Design and Synthesis of Novel Aminoindazole-pyrrolo[2,3-<i>b</i>]pyridine Inhibitors of IKKα That Selectively Perturb Cellular Non-Canonical NF-κB Signalling

The inhibitory-kappaB kinases (IKKs) IKKα and IKKβ play central roles in regulating the non-canonical and canonical NF-κB signalling pathways. Whilst the proteins that transduce the signals of each pathway have been extensively characterised, the clear dissection of the functional roles of IKKα-medi...

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Bibliographic Details
Main Authors: Christopher Riley, Usama Ammar, Aisha Alsfouk, Nahoum G. Anthony, Jessica Baiget, Giacomo Berretta, David Breen, Judith Huggan, Christopher Lawson, Kathryn McIntosh, Robin Plevin, Colin J. Suckling, Louise C. Young, Andrew Paul, Simon P. Mackay
Format: Article
Language:English
Published: MDPI AG 2024-07-01
Series:Molecules
Subjects:
inhibitory κB kinases
IKKα
nuclear factor-κB (NF-κB)
non-canonical NF-κB signalling
IKKα inhibitor
Online Access:https://www.mdpi.com/1420-3049/29/15/3515

Internet

https://www.mdpi.com/1420-3049/29/15/3515

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