APP21 transgenic rats develop age-dependent cognitive impairment and microglia accumulation within white matter tracts

APP21 transgenic rats develop age-dependent cognitive impairment and microglia accumulation within white matter tracts

Abstract Background Most of the animal models commonly used for preclinical research into Alzheimer’s disease (AD) largely fail to address the pathophysiology, including the impact of known risk factors, of the widely diagnosed sporadic form of the disease. Here, we use a transgenic rat (APP21) that...

Full description

Bibliographic Details
Main Authors: Nina Weishaupt, Qingfan Liu, Sheojung Shin, Ramandeep Singh, Yuksel Agca, Cansu Agca, Vladimir Hachinski, Shawn Narain Whitehead
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
White matter inflammation
APP21 transgenic rat
Cognitive impairment
Alzheimer’s disease
Rat model
Online Access:http://link.springer.com/article/10.1186/s12974-018-1273-7

Internet

http://link.springer.com/article/10.1186/s12974-018-1273-7

Similar Items