WAYS TO ENHANCE LYMPHOCYTE TRAFFICKING INTO TUMORS AND FITNESS OF TUMOR INFILTRATING LYMPHOCYTES
The tumor is a hostile microenvironment for T lymphocytes. Indeed, irregular blood flow and endothelial cell (EC) anergy that characterize most solid tumors hamper leukocyte adhesion, extravasation and infiltration. In addition, hypoxia and reprogramming of energy metabolism within cancer cells tran...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00231/full |