WAYS TO ENHANCE LYMPHOCYTE TRAFFICKING INTO TUMORS AND FITNESS OF TUMOR INFILTRATING LYMPHOCYTES

WAYS TO ENHANCE LYMPHOCYTE TRAFFICKING INTO TUMORS AND FITNESS OF TUMOR INFILTRATING LYMPHOCYTES

The tumor is a hostile microenvironment for T lymphocytes. Indeed, irregular blood flow and endothelial cell (EC) anergy that characterize most solid tumors hamper leukocyte adhesion, extravasation and infiltration. In addition, hypoxia and reprogramming of energy metabolism within cancer cells tran...

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Bibliographic Details
Main Authors:	Matteo eBellone, Arianna eCalcinotto
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2013-09-01
Series:	Frontiers in Oncology
Subjects:	Angiogenesis Inhibitors Cancer Vaccines Combined Modality Therapy Dendritic Cells Endothelial Cells Hypoxia-Inducible Factor 1
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00231/full

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