Role of JNK in a Trp53-dependent mouse model of breast cancer.
The cJun NH2-terminal kinase (JNK) signal transduction pathway has been implicated in mammary carcinogenesis. To test the role of JNK, we examined the effect of ablation of the Jnk1 and Jnk2 genes in a Trp53-dependent model of breast cancer using BALB/c mice. We detected no defects in mammary gland...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-08-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2930003?pdf=render |
| _version_ | 1819082517730295808 |
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| author | Cristina Cellurale Claire R Weston Judith Reilly David S Garlick D Joseph Jerry Hayla K Sluss Roger J Davis |
| author_facet | Cristina Cellurale Claire R Weston Judith Reilly David S Garlick D Joseph Jerry Hayla K Sluss Roger J Davis |
| author_sort | Cristina Cellurale |
| collection | DOAJ |
| description | The cJun NH2-terminal kinase (JNK) signal transduction pathway has been implicated in mammary carcinogenesis. To test the role of JNK, we examined the effect of ablation of the Jnk1 and Jnk2 genes in a Trp53-dependent model of breast cancer using BALB/c mice. We detected no defects in mammary gland development in virgin mice or during lactation and involution in control studies of Jnk1(-/-) and Jnk2(-/-) mice. In a Trp53(-/+) genetic background, mammary carcinomas were detected in 43% of control mice, 70% of Jnk1(-/-) mice, and 53% of Jnk2(-/-) mice. These data indicate that JNK1 and JNK2 are not essential for mammary carcinoma development in the Trp53(-/+) BALB/c model of breast cancer. In contrast, this analysis suggests that JNK may partially contribute to tumor suppression. This conclusion is consistent with the finding that tumor-free survival of JNK-deficient Trp53(-/+) mice was significantly reduced compared with control Trp53(-/+) mice. We conclude that JNK1 and JNK2 can act as suppressors of mammary tumor development. |
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| format | Article |
| id | doaj.art-e3edcc8710984e838f206fbeb95f0e60 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T20:17:56Z |
| publishDate | 2010-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e3edcc8710984e838f206fbeb95f0e602022-12-21T18:51:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-08-0158e1246910.1371/journal.pone.0012469Role of JNK in a Trp53-dependent mouse model of breast cancer.Cristina CelluraleClaire R WestonJudith ReillyDavid S GarlickD Joseph JerryHayla K SlussRoger J DavisThe cJun NH2-terminal kinase (JNK) signal transduction pathway has been implicated in mammary carcinogenesis. To test the role of JNK, we examined the effect of ablation of the Jnk1 and Jnk2 genes in a Trp53-dependent model of breast cancer using BALB/c mice. We detected no defects in mammary gland development in virgin mice or during lactation and involution in control studies of Jnk1(-/-) and Jnk2(-/-) mice. In a Trp53(-/+) genetic background, mammary carcinomas were detected in 43% of control mice, 70% of Jnk1(-/-) mice, and 53% of Jnk2(-/-) mice. These data indicate that JNK1 and JNK2 are not essential for mammary carcinoma development in the Trp53(-/+) BALB/c model of breast cancer. In contrast, this analysis suggests that JNK may partially contribute to tumor suppression. This conclusion is consistent with the finding that tumor-free survival of JNK-deficient Trp53(-/+) mice was significantly reduced compared with control Trp53(-/+) mice. We conclude that JNK1 and JNK2 can act as suppressors of mammary tumor development.http://europepmc.org/articles/PMC2930003?pdf=render |
| spellingShingle | Cristina Cellurale Claire R Weston Judith Reilly David S Garlick D Joseph Jerry Hayla K Sluss Roger J Davis Role of JNK in a Trp53-dependent mouse model of breast cancer. PLoS ONE |
| title | Role of JNK in a Trp53-dependent mouse model of breast cancer. |
| title_full | Role of JNK in a Trp53-dependent mouse model of breast cancer. |
| title_fullStr | Role of JNK in a Trp53-dependent mouse model of breast cancer. |
| title_full_unstemmed | Role of JNK in a Trp53-dependent mouse model of breast cancer. |
| title_short | Role of JNK in a Trp53-dependent mouse model of breast cancer. |
| title_sort | role of jnk in a trp53 dependent mouse model of breast cancer |
| url | http://europepmc.org/articles/PMC2930003?pdf=render |
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