Immune Cell-Type Specific Ablation of Adapter Protein ADAP Differentially Modulates EAE

Immune Cell-Type Specific Ablation of Adapter Protein ADAP Differentially Modulates EAE

The cytosolic adhesion and degranulation-promoting adapter protein ADAP is expressed in various hematopoietic cells including T cells, NK cells, myeloid cells, and platelets but absent in mature B cells. The role of ADAP in T cell activation, proliferation and integrin activation is well-accepted. W...

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Bibliographic Details
Main Authors: Jochen Rudolph, Clara Meinke, Martin Voss, Karina Guttek, Stefanie Kliche, Dirk Reinhold, Burkhart Schraven, Annegret Reinhold
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
adapter protein
ADAP
EAE
conditional knockout mice
T cell
NK cell
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02343/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02343/full

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