Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma

Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma

Aberrant expression of cancer genes and non-canonical RNA species is a hallmark of cancer. However, the mechanisms driving such atypical gene expression programs are incompletely understood. Here, our transcriptional profiling of a cohort of 50 primary clear cell renal cell carcinoma (ccRCC) samples...

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Bibliographic Details
Main Authors: Ana R Grosso, Ana P Leite, Sílvia Carvalho, Mafalda R Matos, Filipa B Martins, Alexandra C Vítor, Joana MP Desterro, Maria Carmo-Fonseca, Sérgio F de Almeida
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-11-01
Series:eLife
Subjects:
clear cell renal cell carcinoma
transcription read-through
cancer genes
BCL2 oncogene
RNA chimeras
Online Access:https://elifesciences.org/articles/09214

Internet

https://elifesciences.org/articles/09214

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