Role of epigenetics and the transcription factor Sp1 in the expression of the D prostanoid receptor 1 in human cartilage

Role of epigenetics and the transcription factor Sp1 in the expression of the D prostanoid receptor 1 in human cartilage

D prostanoid receptor 1 (DP1), a prostaglandin D2 receptor, plays a central role in the modulation of inflammation and cartilage metabolism. We have previously shown that activation of DP1 signaling downregulated catabolic responses in cultured chondrocytes and was protective in mouse osteoarthritis...

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Bibliographic Details
Main Authors: Mehdi Najar, Sami G. Alsabri, Gadid G. Guedi, Makram Merimi, Frédéric Lavoie, Detlev Grabs, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Mohamed Benderdour, Hassan Fahmi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
DP1
prostaglandin D2
chondrocyte
Sp1
epigenetics
DNA methylation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1256998/full

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https://www.frontiersin.org/articles/10.3389/fcell.2023.1256998/full

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