An immunogen containing four tandem 10E8 epitope repeats with exposed key residues induces antibodies that neutralize HIV-1 and activates an ADCC reporter gene

An immunogen containing four tandem 10E8 epitope repeats with exposed key residues induces antibodies that neutralize HIV-1 and activates an ADCC reporter gene

After three decades of intensive research efforts, an effective vaccine against HIV-1 remains to be developed. Several broadly neutralizing antibodies to HIV-1, such as 10E8, recognize the membrane proximal external region (MPER) of the HIV-1 gp41 protein. Thus, the MPER is considered to be a very i...

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Bibliographic Details
Main Authors: Zhiwu Sun, Yun Zhu, Qian Wang, Ling Ye, Yanyan Dai, Shan Su, Fei Yu, Tianlei Ying, Chinglai Yang, Shibo Jiang, Lu Lu
Format: Article
Language:English
Published: Taylor & Francis Group 2016-01-01
Series:Emerging Microbes and Infections
Subjects:
ADCC
HIV-1
neutralizing antibodies
10E8 epitopes
Online Access:https://www.tandfonline.com/doi/10.1038/emi.2016.86

Internet

https://www.tandfonline.com/doi/10.1038/emi.2016.86

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