A new thiol-independent mechanism of epithelial host defense against Pseudomonas aeruginosa: iNOS/NO• sabotage of theft-ferroptosis

Ferroptosis is a redox-driven type of regulated cell death program arising from maladaptation of three metabolic pathways: glutathione homeostasis, iron handling and lipid peroxidation. Though GSH/Gpx4 is the predominant system detoxifying phospholipid hydroperoxides (PLOOH) in mammalian cells, rece...

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Bibliographic Details
Main Authors: Haider H. Dar, Tamil S. Anthonymuthu, Liubov A. Ponomareva, Austin B. Souryavong, Galina V. Shurin, Alexandr O. Kapralov, Vladimir A. Tyurin, Janet S. Lee, Rama K. Mallampalli, Sally E. Wenzel, Hülya Bayir, Valerian E. Kagan
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Redox Biology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721002044