An AI‐assisted integrated, scalable, single‐cell phenomic‐transcriptomic platform to elucidate intratumor heterogeneity against immune response

An AI‐assisted integrated, scalable, single‐cell phenomic‐transcriptomic platform to elucidate intratumor heterogeneity against immune response

Abstract We present a novel framework combining single‐cell phenotypic data with single‐cell transcriptomic analysis to identify factors underpinning heterogeneity in antitumor immune response. We developed a pairwise, tumor‐immune discretized interaction assay between natural killer (NK‐92MI) cells...

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Bibliographic Details
Main Authors: Christopher P. Tostado, Lucas Xian Da Ong, Joel Jia Wei Heng, Carlo Miccolis, Shumei Chia, Justine Jia Wen Seow, Yi‐Chin Toh, Ramanuj DasGupta
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Bioengineering & Translational Medicine
Subjects:
computer vision
head and neck cancer
immunotherapy
microfluidics
precision oncology
single‐cell transcriptomics
Online Access:https://doi.org/10.1002/btm2.10628

Internet

https://doi.org/10.1002/btm2.10628

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