Neuroprotective Effect of 1,4-Naphthoquinones in an <i>In Vitro</i> Model of Paraquat and 6-OHDA-Induced Neurotoxicity

Neuroprotective Effect of 1,4-Naphthoquinones in an <i>In Vitro</i> Model of Paraquat and 6-OHDA-Induced Neurotoxicity

Targeted screening using the MTT cell viability test with a mini-library of natural and synthetic 1,4-naphthoquinones and their derivatives was performed in order to increase the survival of Neuro-2a neuroblastoma cells in in vitro paraquat and 6-hydroxydopamine models of Parkinson’s disease. As a r...

Full description

Bibliographic Details
Main Authors: Ekaterina Menchinskaya, Ekaterina Chingizova, Evgeny Pislyagin, Galina Likhatskaya, Yuri Sabutski, Dmitry Pelageev, Sergei Polonik, Dmitry Aminin
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
1,4-naphthoquinones
neuronal cells
paraquat
6-hydroxydopamine
cell viability
reactive oxygen species and nitric oxide production
Online Access:https://www.mdpi.com/1422-0067/22/18/9933

Internet

https://www.mdpi.com/1422-0067/22/18/9933

Similar Items