Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN

Abstract Circular RNAs (circRNAs) are a regulatory RNA class. While cancer-driving functions have been identified for single circRNAs, how they modulate gene expression in cancer is not well understood. We investigate circRNA expression in the pediatric malignancy, neuroblastoma, through deep whole-...

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Bibliographic Details
Main Authors: Steffen Fuchs, Clara Danßmann, Filippos Klironomos, Annika Winkler, Jörg Fallmann, Louisa-Marie Kruetzfeldt, Annabell Szymansky, Julian Naderi, Stephan H. Bernhart, Laura Grunewald, Konstantin Helmsauer, Elias Rodriguez-Fos, Marieluise Kirchner, Philipp Mertins, Kathy Astrahantseff, Christin Suenkel, Joern Toedling, Fabienne Meggetto, Marc Remke, Peter F. Stadler, Patrick Hundsdoerfer, Hedwig E. Deubzer, Annette Künkele, Peter Lang, Jörg Fuchs, Anton G. Henssen, Angelika Eggert, Nikolaus Rajewsky, Falk Hertwig, Johannes H. Schulte
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38747-4

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https://doi.org/10.1038/s41467-023-38747-4

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