Nebulization of risedronate alleviates airway obstruction and inflammation of chronic obstructive pulmonary diseases via suppressing prenylation-dependent RAS/ERK/NF-κB and RhoA/ROCK1/MLCP signaling

Nebulization of risedronate alleviates airway obstruction and inflammation of chronic obstructive pulmonary diseases via suppressing prenylation-dependent RAS/ERK/NF-κB and RhoA/ROCK1/MLCP signaling

Abstract Background Chronic obstructive pulmonary disease (COPD) is a progressive disorder that causes airway obstruction and lung inflammation. The first-line treatment of COPD is the bronchodilators of β2-agonists and antimuscarinic drugs, which can help control the airway obstruction, but the lon...

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Bibliographic Details
Main Authors: Di Liu, Wen Xu, Yuan Tang, Jingxue Cao, Ran Chen, Dingwei Wu, Hongpeng Chen, Bo Su, Jinfu Xu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Respiratory Research
Subjects:
Pulmonary disease
Chronic obstructive
Risedronic acid
Inflammation
Animal models
Online Access:https://doi.org/10.1186/s12931-022-02274-5

Internet

https://doi.org/10.1186/s12931-022-02274-5

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