Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults

Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults

Mitochondrial dysfunction and iron (Fe) dyshomeostasis are invoked among the mechanisms contributing to muscle aging, possibly via a detrimental mitochondrial–iron feed-forward loop. We quantified the labile Fe pool, Fe isotopes, and the expression of mitochondrial Fe handling proteins in muscle bio...

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Bibliographic Details
Main Authors: Anna Picca, Sunil K. Saini, Robert T. Mankowski, George Kamenov, Stephen D. Anton, Todd M. Manini, Thomas W. Buford, Stephanie E. Wohlgemuth, Rui Xiao, Riccardo Calvani, Hélio José Coelho-Júnior, Francesco Landi, Roberto Bernabei, David A. Hood, Emanuele Marzetti, Christiaan Leeuwenburgh
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cells
Subjects:
autophagy
iron dyshomeostasis
iron metabolism
iron isotopes
mitochondria
mitochondrial quality control
Online Access:https://www.mdpi.com/2073-4409/9/12/2579

Internet

https://www.mdpi.com/2073-4409/9/12/2579

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