The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development

The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development

Genetic changes in the HECT ubiquitin ligase HUWE1 are associated with intellectual disability, but it remains unknown whether HUWE1 functions in post-mitotic neurons to affect circuit function. Using genetics, pharmacology, and electrophysiology, we show that EEL-1, the HUWE1 ortholog in C. elegans...

Full description

Bibliographic Details
Main Authors: Karla J. Opperman, Ben Mulcahy, Andrew C. Giles, Monica G. Risley, Rayna L. Birnbaum, Erik D. Tulgren, Ken Dawson-Scully, Mei Zhen, Brock Grill
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Cell Reports
Subjects:
EEL-1
HUWE1
intellectual disability
motor neuron
C. elegans
RPM-1
GABA
synaptic transmission
acetylcholine
seizure
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471730462X

Internet

http://www.sciencedirect.com/science/article/pii/S221112471730462X

Similar Items