The scaffolding function of LSD1/KDM1A reinforces a negative feedback loop to repress stem cell gene expression during primitive hematopoiesis

The scaffolding function of LSD1/KDM1A reinforces a negative feedback loop to repress stem cell gene expression during primitive hematopoiesis

Summary: Lsd1/Kdm1a functions both as a histone demethylase enzyme and as a scaffold for assembling chromatin modifier and transcription factor complexes to regulate gene expression. The relative contributions of Lsd1’s demethylase and scaffolding functions during embryogenesis are not known. Here,...

Full description

Bibliographic Details
Main Authors: Mattie J. Casey, Alexandra M. Call, Annika V. Thorpe, Cicely A. Jette, Michael E. Engel, Rodney A. Stewart
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:iScience
Subjects:
Molecular biology
Molecular interaction
Cell biology
Stem cells research
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222020107

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222020107

Similar Items