The scaffolding function of LSD1/KDM1A reinforces a negative feedback loop to repress stem cell gene expression during primitive hematopoiesis

The scaffolding function of LSD1/KDM1A reinforces a negative feedback loop to repress stem cell gene expression during primitive hematopoiesis

Summary: Lsd1/Kdm1a functions both as a histone demethylase enzyme and as a scaffold for assembling chromatin modifier and transcription factor complexes to regulate gene expression. The relative contributions of Lsd1’s demethylase and scaffolding functions during embryogenesis are not known. Here,...

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Bibliographic Details
Main Authors: Mattie J. Casey, Alexandra M. Call, Annika V. Thorpe, Cicely A. Jette, Michael E. Engel, Rodney A. Stewart
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:iScience
Subjects:
Molecular biology
Molecular interaction
Cell biology
Stem cells research
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222020107

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