Dapagliflozin Improves Cardiac Hemodynamics and Mitigates Arrhythmogenesis in Mitral Regurgitation‐Induced Myocardial Dysfunction

Dapagliflozin Improves Cardiac Hemodynamics and Mitigates Arrhythmogenesis in Mitral Regurgitation‐Induced Myocardial Dysfunction

Background Mitral regurgitation (MR) is a major contributor for heart failure (HF) and atrial fibrillation. Despite the advancement of MR surgeries, an effective medical therapy to mitigate MR progression is lacking. Sodium glucose cotransporter 2 inhibitors, a new class of antidiabetic drugs, has s...

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Bibliographic Details
Main Authors: Yu‐Wen Lin, Chin‐Yu Chen, Jhih‐Yuan Shih, Bor‐Chih Cheng, Ching‐Ping Chang, Mao‐Tsun Lin, Chung‐Han Ho, Zhih‐Cherng Chen, Sudeshna Fisch, Wei‐Ting Chang
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
apoptosis
cardiac fibrosis
dapagliflozin
ER stress
heart failure
mitral regurgitation
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.019274

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https://www.ahajournals.org/doi/10.1161/JAHA.120.019274

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