Role of CAR T Cell Metabolism for Therapeutic Efficacy

Chimeric antigen receptor (CAR) T cells hold enormous potential. However, a substantial proportion of patients receiving CAR T cells will not reach long-term full remission. One of the causes lies in their premature exhaustion, which also includes a metabolic anergy of adoptively transferred CAR T c...

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Bibliographic Details
Main Authors: Judit Rial Saborido, Simon Völkl, Michael Aigner, Andreas Mackensen, Dimitrios Mougiakakos
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/14/21/5442