Stability evaluation of compounded hydroxyurea 100 mg/mL oral liquids using a novel analytical method involving chemical derivatization.

Stability evaluation of compounded hydroxyurea 100 mg/mL oral liquids using a novel analytical method involving chemical derivatization.

This study assessed the stability of six extemporaneously compounded hydroxyurea oral liquids stored at room temperature. Hydroxyurea oral liquids (100 mg/mL) were prepared using three different mixing methods (mortar, mixer or QuartetRx) from either bulk powder, capsule content, or whole capsules....

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Bibliographic Details
Main Authors: Daphné Coache, Mihaela Friciu, Ruth Bernine Marcellin, Lola Bonnemain, Annie Viau, V Gaëlle Roullin, Jean-Marc Forest, Grégoire Leclair
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0270206

Internet

https://doi.org/10.1371/journal.pone.0270206

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