Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease

Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease

Machado-Joseph disease (MJD) or Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder that affects movement coordination leading to a premature death. Despite several efforts, no disease-modifying treatment is yet available for this disease. Previous studies pinpointed the...

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Détails bibliographiques
Auteurs principaux: Joana Pereira-Sousa, Bruna Ferreira-Lomba, Aina Bellver-Sanchis, Daniela Vilasboas-Campos, Jorge H. Fernandes, Marta D. Costa, Mark A. Varney, Adrian Newman-Tancredi, Patrícia Maciel, Andreia Teixeira-Castro
Format: Article
Langue:English
Publié: Elsevier 2021-05-01
Collection:Neurobiology of Disease
Sujets:
Befiradol
NLX-112
5-HT1A receptor agonist
Spinocerebellar ataxia type 3
Ataxin-3 aggregation
Serotonin
Accès en ligne:http://www.sciencedirect.com/science/article/pii/S0969996121000279

Internet

http://www.sciencedirect.com/science/article/pii/S0969996121000279

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