Epstein-Barr virus infectious particles initiate B cell transformation and modulate cytokine response

ABSTRACT The Epstein-Barr virus (EBV) efficiently transforms primary B cells. Here, we show that this process starts immediately after cellular exposure to infectious viral particles. Virus binding to B cells led to the activation of intracytoplasmic tyrosine kinases and STAT3. Tegument proteins wit...

Full description

Bibliographic Details
Main Authors: Francesco Baccianti, Charlène Masson, Susanne Delecluse, Zhe Li, Remy Poirey, Henri-Jacques Delecluse
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/mbio.01784-23