Characterization of DNA damage repair pathway utilization in high-grade serous ovarian cancers yields rational therapeutic approaches

Characterization of DNA damage repair pathway utilization in high-grade serous ovarian cancers yields rational therapeutic approaches

While poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have improved the prognosis of ovarian high-grade serous carcinoma (HGSC) tumors that are homologous recombination (HR) deficient (HRD), new therapeutic strategies are needed for tumors that are HR proficient (HRP) because they demonstrate...

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Bibliographic Details
Main Authors: Erika Nakatsuka, Lijun Tan, Brianna Cunneen, Caroline Foster, Yu Leo Lei, Karen McLean
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Translational Oncology
Subjects:
DNA damage repair
Homologous recombination
Non-homologous end-joining
ATM
PARP
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523324002468

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http://www.sciencedirect.com/science/article/pii/S1936523324002468

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