SAGA–CORE subunit Spt7 is required for correct Ubp8 localization, chromatin association and deubiquitinase activity

SAGA–CORE subunit Spt7 is required for correct Ubp8 localization, chromatin association and deubiquitinase activity

Abstract Background Histone H2B deubiquitination is performed by numerous deubiquitinases in eukaryotic cells including Ubp8, the catalytic subunit of the tetrameric deubiquitination module (DUBm: Ubp8; Sus1; Sgf11; Sgf73) of the Spt-Ada-Gcn5 acetyltransferase (SAGA). Ubp8 is linked to the rest of S...

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Bibliographic Details
Main Authors: Carme Nuño-Cabanes, Varinia García-Molinero, Manuel Martín-Expósito, María-Eugenia Gas, Paula Oliete-Calvo, Encar García-Oliver, María de la Iglesia-Vayá, Susana Rodríguez-Navarro
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Epigenetics & Chromatin
Subjects:
SAGA
Histone deubiquitination
Spt7
Transcription
Yeast
Online Access:http://link.springer.com/article/10.1186/s13072-020-00367-3

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http://link.springer.com/article/10.1186/s13072-020-00367-3

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