Dual-target ligand discovery for Alzheimer’s disease: triphenylphosphoranylidene derivatives as inhibitors of acetylcholinesterase and β-amyloid aggregation

Dual-target ligand discovery for Alzheimer’s disease: triphenylphosphoranylidene derivatives as inhibitors of acetylcholinesterase and β-amyloid aggregation

AbstractAlzheimer disease (AD) is one of the major neurodegenerative diseases that could not be prevented or completely cured and may lead to death. Here, we target AChE and β-amyloid proteins. Synthesising new triphenylphosphporanylidene derivatives based on the surveyed literature and testing thei...

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Bibliographic Details
Main Authors: Marwa El-Hussieny, Mansoura A. Abd-El-Maksoud, Fouad M. Soliman, Marwa A. Fouad, Mohamed K. El-Ashrey
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Triphenylphosphoranylidene
silane
acetylcholinesterase
β-amyloid
Alzheimer’s disease
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2166040

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2023.2166040

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