Diabetes Perturbs Bone Microarchitecture and Bone Strength through Regulation of Sema3A/IGF-1/β-Catenin in Rats

Diabetes Perturbs Bone Microarchitecture and Bone Strength through Regulation of Sema3A/IGF-1/β-Catenin in Rats

Purpose: Increasing evidence supported that semaphorin 3A (Sema3A), insulin-like growth factor (IGF)-1 and β-catenin were involved in the development of osteoporosis and diabetes. This study is aimed to evaluate whether Sema3A/IGF-1/β-catenin is directly involved in the alterations of bone microarch...

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Bibliographic Details
Main Authors: Rufeng Ma, Lili Wang, Baosheng Zhao, Chenyue Liu, Haixia Liu, Ruyuan Zhu, Beibei Chen, Lin Li, Dandan Zhao, Fangfang Mo, Yu Li, Jianzhao Niu, Guangjian Jiang, Min Fu, Dieter Bromme, Sihua Gao, Dongwei Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-01-01
Series:Cellular Physiology and Biochemistry
Subjects:
Diabetic rats
Sema3A
β-catenin
Insulin-like growth factor-1 (IGF)
Peroxisome proliferator-activated receptor γ (PPAR γ)
Cathepsin K
Online Access:http://www.karger.com/Article/FullText/455936

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http://www.karger.com/Article/FullText/455936

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