Amyloid-β specific regulatory T cells attenuate Alzheimer’s disease pathobiology in APP/PS1 mice

Amyloid-β specific regulatory T cells attenuate Alzheimer’s disease pathobiology in APP/PS1 mice

Abstract Background Regulatory T cells (Tregs) maintain immune tolerance. While Treg-mediated neuroprotective activities are now well-accepted, the lack of defined antigen specificity limits their therapeutic potential. This is notable for neurodegenerative diseases where cell access to injured brai...

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Bibliographic Details
Main Authors: Pravin Yeapuri, Jatin Machhi, Yaman Lu, Mai Mohamed Abdelmoaty, Rana Kadry, Milankumar Patel, Shaurav Bhattarai, Eugene Lu, Krista L. Namminga, Katherine E. Olson, Emma G. Foster, R. Lee Mosley, Howard E. Gendelman
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Molecular Neurodegeneration
Subjects:
Treg cell therapy
Alzheimer’s disease
Immunotherapy
Antigen specific
T cell receptor
Amyloid beta
Online Access:https://doi.org/10.1186/s13024-023-00692-7

Internet

https://doi.org/10.1186/s13024-023-00692-7

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