Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons

Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons

Abstract Neuronal stress-adaptation combines multiple molecular responses. We have previously reported that thorax trauma induces a transient loss of hippocampal excitatory synapses mediated by the local release of the stress-related hormone corticotropin-releasing hormone (CRH). Since a physiologic...

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Bibliographic Details
Main Authors: Chiara R. Battaglia, Silvia Cursano, Enrico Calzia, Alberto Catanese, Tobias M. Boeckers
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-020-03204-3

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https://doi.org/10.1038/s41419-020-03204-3

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