Approved Small-Molecule ATP-Competitive Kinases Drugs Containing Indole/Azaindole/Oxindole Scaffolds: R&D and Binding Patterns Profiling

Approved Small-Molecule ATP-Competitive Kinases Drugs Containing Indole/Azaindole/Oxindole Scaffolds: R&D and Binding Patterns Profiling

Kinases are among the most important families of biomolecules and play an essential role in the regulation of cell proliferation, apoptosis, metabolism, and other critical physiological processes. The dysregulation and gene mutation of kinases are linked to the occurrence and development of various...

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Bibliographic Details
Main Authors: Haofan Zhang, Fengming He, Guiping Gao, Sheng Lu, Qiaochu Wei, Hongyu Hu, Zhen Wu, Meijuan Fang, Xiumin Wang
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
indole/azaindole/oxindole derivatives
approved ATP-competitive kinases drugs
cancer
drug design
kinases binding patterns
drug discovery
Online Access:https://www.mdpi.com/1420-3049/28/3/943

Internet

https://www.mdpi.com/1420-3049/28/3/943

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