Signatures of selection and drivers for novel mutation on transmission-blocking vaccine candidate Pfs25 gene in western Kenya.

Signatures of selection and drivers for novel mutation on transmission-blocking vaccine candidate Pfs25 gene in western Kenya.

<h4>Background</h4>Leading transmission-blocking vaccine candidates such as Plasmodium falciparum surface protein 25 (Pfs25 gene) may undergo antigenic alterations which may render them ineffective or allele-specific. This study examines the level of genetic diversity, signature of selec...

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Bibliographic Details
Main Authors: Kevin O Ochwedo, Shirley A Onyango, Collince J Omondi, Pauline W Orondo, Benyl M Ondeto, Ming-Chieh Lee, Harrysone E Atieli, Sidney O Ogolla, Andrew K Githeko, Antony C A Otieno, Wolfgang R Mukabana, Guiyun Yan, Daibin Zhong, James W Kazura
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0266394

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https://doi.org/10.1371/journal.pone.0266394

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