Mechanistic insights into the rational design of masked antibodies

Mechanistic insights into the rational design of masked antibodies

Although monoclonal antibodies have greatly improved cancer therapy, they can trigger side effects due to on-target, off-tumor toxicity. Over the past decade, strategies have emerged to successfully mask the antigen-binding site of antibodies, such that they are only activated at the relevant site,...

Full description

Bibliographic Details
Main Authors: Carolina T. Orozco, Manuela Bersellini, Lorraine M. Irving, Wesley W. Howard, David Hargreaves, Paul W. A. Devine, Elise Siouve, Gareth J. Browne, Nicholas J. Bond, Jonathan J. Phillips, Peter Ravn, Sophie E. Jackson
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:mAbs
Subjects:
Masked antibodies
off-tumor cytotoxicity
protein design
pro-antibody
pro-drug
protein-protein interaction
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2022.2095701

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2022.2095701

Similar Items