Knock-Out of the Five Lysyl-Oxidase Family Genes Enables Identification of Lysyl-Oxidase Pro-Enzyme Regulated Genes

Knock-Out of the Five Lysyl-Oxidase Family Genes Enables Identification of Lysyl-Oxidase Pro-Enzyme Regulated Genes

The five lysyl-oxidase genes share similar enzymatic activities and contribute to tumor progression. We have knocked out the five lysyl-oxidase genes in MDA-MB-231 breast cancer cells using CRISPR/Cas9 in order to identify genes that are regulated by LOX but not by other lysyl-oxidases and in order...

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Bibliographic Details
Main Authors: Tatyana Liburkin-Dan, Inbal Nir-Zvi, Hila Razon, Ofra Kessler, Gera Neufeld
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
lysyl-oxidase
breast cancer
Online Access:https://www.mdpi.com/1422-0067/23/19/11322

Internet

https://www.mdpi.com/1422-0067/23/19/11322

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