A neuronal cell-based reporter system for monitoring the activity of HDAC2

Given that histone acetylation via histone acetyltransferases (HATs) and histone deacetylases (HDACs) is significant in memory formation, HDAC2 has been thoroughly investigated as a potential therapeutic target for the treatment of cognitive dysfunction. Although HDAC inhibitors have been discovered...

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Bibliographic Details
Main Authors: Kazuhiro Unemura, Masako Kawano, Mai Takakura, Ikuko Iwata, Kana Hyakkoku, Naotaka Horiguchi, Tomohiko Okuda, Yukinori Hirano
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:SLAS Discovery
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555222137020