Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

Abstract Background The role of the alternative complement pathway and its mediation by retinal microglia and macrophages, is well-established in the pathogenesis of Age-Related Macular Degeneration (AMD). However, the contribution of the classical complement pathway towards the progression of retin...

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Bibliographic Details
Main Authors: Haihan Jiao, Matt Rutar, Nilisha Fernando, Ted Yednock, Sethu Sankaranarayanan, Riemke Aggio-Bruce, Jan Provis, Riccardo Natoli
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Molecular Neurodegeneration
Subjects:
Macrophages
Microglia
Complement system
Classical pathway
C1q
Inflammasome
Online Access:http://link.springer.com/article/10.1186/s13024-018-0278-0

Internet

http://link.springer.com/article/10.1186/s13024-018-0278-0

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