A Reverse Mutation E143K within the PrM Protein of Zika Virus Asian Lineage Natal RGN Strain Increases Infectivity and Cytopathicity

A Reverse Mutation E143K within the PrM Protein of Zika Virus Asian Lineage Natal RGN Strain Increases Infectivity and Cytopathicity

Zika virus (ZIKV) is a positive-sense single-stranded RNA virus in the Flaviviridae, which is classified into two different lineages Asian and African. The outbreak of ZIKV Asian lineage isolates in 2015–2016 is associated with the increase in cases with prenatal microcephaly and Guillain–Barré synd...

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Bibliographic Details
Main Authors: Chen-Sheng Lin, Wei-Jing Li, Chih-Yi Liao, Ju-Ying Kan, Szu-Hao Kung, Su-Hua Huang, Hsueh-Chou Lai, Cheng-Wen Lin
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Viruses
Subjects:
Zika virus
Asian lineage
prM
amino acid substitution
single round infectious particle (SRIP)
infectious clone (i.c.)
Online Access:https://www.mdpi.com/1999-4915/14/7/1572

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https://www.mdpi.com/1999-4915/14/7/1572

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