Continuous influenza virus production in cell culture shows a periodic accumulation of defective interfering particles.

Influenza viruses are a major public health burden during seasonal epidemics and a continuous threat due to their potential to cause pandemics. Annual vaccination provides the best protection against the contagious respiratory illness caused by influenza viruses. However, the current production capa...

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Bibliographic Details
Main Authors: Timo Frensing, Frank Stefan Heldt, Antje Pflugmacher, Ilona Behrendt, Ingo Jordan, Dietrich Flockerzi, Yvonne Genzel, Udo Reichl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24039749/pdf/?tool=EBI