Hibiscetin attenuates oxidative, nitrative stress and neuroinflammation via suppression of TNF-α signaling in rotenone induced parkinsonism in rats
Parkinson's disease (PD) is the gradual and selective degradation of dopamine-releasing neurons in substantia nigra pars compacta (SNpc) and results in postural instability, stiffness, bradykinesia, and resting tremor. The goal of this research was to see how hibiscetin action on PD in rotenone...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Saudi Pharmaceutical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S131901642200247X |
| _version_ | 1828088651364433920 |
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| author | Sami I. Alzarea Muhammad Afzal Khalid Saad Alharbi Abdulaziz I. Alzarea Sattam Khulaif Alenezi Mohammed Salem Alshammari Ali Alquraini Imran Kazmi |
| author_facet | Sami I. Alzarea Muhammad Afzal Khalid Saad Alharbi Abdulaziz I. Alzarea Sattam Khulaif Alenezi Mohammed Salem Alshammari Ali Alquraini Imran Kazmi |
| author_sort | Sami I. Alzarea |
| collection | DOAJ |
| description | Parkinson's disease (PD) is the gradual and selective degradation of dopamine-releasing neurons in substantia nigra pars compacta (SNpc) and results in postural instability, stiffness, bradykinesia, and resting tremor. The goal of this research was to see how hibiscetin action on PD in rotenone-treated rats. Rats were administered orally with hibiscetin (10 mg/kg) after 1 h rotenone (0.5 mg/kg, s.c.). This therapy regimen was followed on a daily basis for 28 days.Rats were tested for catalepsy and akinesia on day 29 after the last dosage of rotenone. Biochemical parameters were performed to measure reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), nitrite, neuroinflammatory cytokines, and neurotransmitter and their metabolite levels such as dopamine (DA), norepinephrine (NE), serotonin (5-HT), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA). Rotenone-induced akinesia and catatonia in rats decreased endogenous antioxidant (GSH, CAT, and SOD) levels, increased MDA and nitrite levels, and changed neurotransmitter and metabolite levels. Hibiscetin effectively reduced rotenone-induced akinesia and catatonia, improved endogenous antioxidant (GSH, CAT and SOD) levels, and reduced oxidative and nitrative stress in the treated rats. Moreover, hibiscetin restored altered neurotransmitters and their metabolites to normal levels in rotenone-treated rats. The study results showed that hibiscetin has anti-Parkinson's activity against rotenone-induced PD in rats. |
| first_indexed | 2024-04-11T05:28:43Z |
| format | Article |
| id | doaj.art-e43e27783bf549af9e2ac4b932be0edc |
| institution | Directory Open Access Journal |
| issn | 1319-0164 |
| language | English |
| last_indexed | 2024-04-11T05:28:43Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Pharmaceutical Journal |
| spelling | doaj.art-e43e27783bf549af9e2ac4b932be0edc2022-12-23T04:39:57ZengElsevierSaudi Pharmaceutical Journal1319-01642022-12-01301217101717Hibiscetin attenuates oxidative, nitrative stress and neuroinflammation via suppression of TNF-α signaling in rotenone induced parkinsonism in ratsSami I. Alzarea0Muhammad Afzal1Khalid Saad Alharbi2Abdulaziz I. Alzarea3Sattam Khulaif Alenezi4Mohammed Salem Alshammari5Ali Alquraini6Imran Kazmi7Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi ArabiaDepartment of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia; Corresponding authors.Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi ArabiaDepartment of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Qassim, Saudi ArabiaDepartment of Pharmacy Practice, Unaizah College of Pharmacy, Qassim University, Qassim, Saudi ArabiaDepartment of Pharmaceutical Chemistry, Faculty of Clinical Pharmacy, Al Baha University, Al Baha 65779, Saudi ArabiaDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Corresponding authors.Parkinson's disease (PD) is the gradual and selective degradation of dopamine-releasing neurons in substantia nigra pars compacta (SNpc) and results in postural instability, stiffness, bradykinesia, and resting tremor. The goal of this research was to see how hibiscetin action on PD in rotenone-treated rats. Rats were administered orally with hibiscetin (10 mg/kg) after 1 h rotenone (0.5 mg/kg, s.c.). This therapy regimen was followed on a daily basis for 28 days.Rats were tested for catalepsy and akinesia on day 29 after the last dosage of rotenone. Biochemical parameters were performed to measure reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), nitrite, neuroinflammatory cytokines, and neurotransmitter and their metabolite levels such as dopamine (DA), norepinephrine (NE), serotonin (5-HT), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA). Rotenone-induced akinesia and catatonia in rats decreased endogenous antioxidant (GSH, CAT, and SOD) levels, increased MDA and nitrite levels, and changed neurotransmitter and metabolite levels. Hibiscetin effectively reduced rotenone-induced akinesia and catatonia, improved endogenous antioxidant (GSH, CAT and SOD) levels, and reduced oxidative and nitrative stress in the treated rats. Moreover, hibiscetin restored altered neurotransmitters and their metabolites to normal levels in rotenone-treated rats. The study results showed that hibiscetin has anti-Parkinson's activity against rotenone-induced PD in rats.http://www.sciencedirect.com/science/article/pii/S131901642200247XFlavonoidsHibiscetinNeurodegenerationNeuroinflammationNeuroprotective |
| spellingShingle | Sami I. Alzarea Muhammad Afzal Khalid Saad Alharbi Abdulaziz I. Alzarea Sattam Khulaif Alenezi Mohammed Salem Alshammari Ali Alquraini Imran Kazmi Hibiscetin attenuates oxidative, nitrative stress and neuroinflammation via suppression of TNF-α signaling in rotenone induced parkinsonism in rats Saudi Pharmaceutical Journal Flavonoids Hibiscetin Neurodegeneration Neuroinflammation Neuroprotective |
| title | Hibiscetin attenuates oxidative, nitrative stress and neuroinflammation via suppression of TNF-α signaling in rotenone induced parkinsonism in rats |
| title_full | Hibiscetin attenuates oxidative, nitrative stress and neuroinflammation via suppression of TNF-α signaling in rotenone induced parkinsonism in rats |
| title_fullStr | Hibiscetin attenuates oxidative, nitrative stress and neuroinflammation via suppression of TNF-α signaling in rotenone induced parkinsonism in rats |
| title_full_unstemmed | Hibiscetin attenuates oxidative, nitrative stress and neuroinflammation via suppression of TNF-α signaling in rotenone induced parkinsonism in rats |
| title_short | Hibiscetin attenuates oxidative, nitrative stress and neuroinflammation via suppression of TNF-α signaling in rotenone induced parkinsonism in rats |
| title_sort | hibiscetin attenuates oxidative nitrative stress and neuroinflammation via suppression of tnf α signaling in rotenone induced parkinsonism in rats |
| topic | Flavonoids Hibiscetin Neurodegeneration Neuroinflammation Neuroprotective |
| url | http://www.sciencedirect.com/science/article/pii/S131901642200247X |
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