Elabela Attenuates the TGF-β1-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Patients Receiving Peritoneal Dialysis

Elabela Attenuates the TGF-β1-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Patients Receiving Peritoneal Dialysis

Peritoneal fibrosis (PF), a common complication in patients receiving peritoneal dialysis (PD), is primarily caused by the epithelial-mesenchymal transition (EMT) of human peritoneal mesothelial cells (HPMCs). PF is the main reason for patients on PD to withdraw from PD. Effective treatment is unava...

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Bibliographic Details
Main Authors: Shunyun Xie, Feng Xu, Yue Lu, Yixian Zhang, Xinyang Li, Mengyuan Yu, Wenpeng Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
peritoneal fibrosis
apelin
HPMCs
EMT
chronic kidney disease
TGF-beta/SMAD/ERK/AKT pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.890881/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.890881/full

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