Rho Kinase Regulates Aortic Vascular Smooth Muscle Cell Stiffness Via Actin/SRF/Myocardin in Hypertension

Rho Kinase Regulates Aortic Vascular Smooth Muscle Cell Stiffness Via Actin/SRF/Myocardin in Hypertension

Background/Aims: Our previous studies demonstrated that intrinsic aortic smooth muscle cell (VSMC) stiffening plays a pivotal role in aortic stiffening in aging and hypertension. However, the underlying molecular mechanisms remain largely unknown. We here hypothesized that Rho kinase (ROCK) acts as...

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Bibliographic Details
Main Authors: Ning Zhou, Jia-Jye Lee, Shaunrick Stoll, Ben Ma, Kevin D. Costa, Hongyu Qiu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Aortic stiffness
Atomic force microscopy
Hypertension
Rho kinase
Vascular smooth muscle cell
Serum response factor
Myocardin
Online Access:https://www.karger.com/Article/FullText/485284

Internet

https://www.karger.com/Article/FullText/485284

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