The Antimicrobial Activity of a Carbon Monoxide Releasing Molecule (EBOR-CORM-1) Is Shaped by Intraspecific Variation within Pseudomonas aeruginosa Populations

The Antimicrobial Activity of a Carbon Monoxide Releasing Molecule (EBOR-CORM-1) Is Shaped by Intraspecific Variation within Pseudomonas aeruginosa Populations

Carbon monoxide releasing molecules (CORMs) have been suggested as a new synthetic class of antimicrobials to treat bacterial infections. Here we utilized a novel EBOR-CORM-1 ([NEt4][MnBr2(CO)4]) capable of water-triggered CO-release, and tested its efficacy against a collection of clinical Pseudomo...

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Bibliographic Details
Main Authors: Lindsey Flanagan, Rachel R. Steen, Karinna Saxby, Mirre Klatter, Benjamin J. Aucott, Craig Winstanley, Ian J. S. Fairlamb, Jason M. Lynam, Alison Parkin, Ville-Petri Friman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Microbiology
Subjects:
biofilms
carbon monoxide releasing molecules
CORM
cystic fibrosis
polymicrobial infections
Pseudomonas aeruginosa
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00195/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00195/full

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