Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice

Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice

Abstract Background Calcific aortic valve disease (CAVD) is the most prevalent valvular disease and has high morbidity and mortality. CAVD is characterized by complex pathophysiological processes, including inflammation-induced osteoblastic differentiation in aortic valve interstitial cells (AVICs)....

Full description

Bibliographic Details
Main Authors: Shunyi Li, Zichao Luo, Shuwen Su, Liming Wen, Gaopeng Xian, Jing Zhao, Xingbo Xu, Dingli Xu, Qingchun Zeng
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Medicine
Subjects:
Calcific aortic valve disease
PTPN22
Natural product
Osteogenic responses
Mitochondrial stress
Online Access:https://doi.org/10.1186/s12916-023-02888-6

Internet

https://doi.org/10.1186/s12916-023-02888-6

Similar Items