The carbon monoxide prodrug oCOm‐21 increases Ca2+ sensitivity of the cardiac myofilament

The carbon monoxide prodrug oCOm‐21 increases Ca2+ sensitivity of the cardiac myofilament

Abstract Patients undergoing cardiopulmonary bypass procedures require inotropic support to improve hemodynamic function and cardiac output. Current inotropes such as dobutamine, can promote arrhythmias, prompting a demand for improved inotropes with little effect on intracellular Ca2+ flux. Low‐dos...

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Bibliographic Details
Main Authors: Fergus M. Payne, Samantha Nie, Gary M. Diffee, Gerard T. Wilkins, David S. Larsen, Joanne C. Harrison, James C. Baldi, Ivan A. Sammut
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Physiological Reports
Subjects:
calcium sensitivity
carbon monoxide
heme
myofilament
Online Access:https://doi.org/10.14814/phy2.15974

Internet

https://doi.org/10.14814/phy2.15974

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