Angiotensin II-Induced Cardiovascular Fibrosis Is Attenuated by NO-Sensitive Guanylyl Cyclase1

Angiotensin II-Induced Cardiovascular Fibrosis Is Attenuated by NO-Sensitive Guanylyl Cyclase1

In the NO/cGMP signaling cascade, relevant in the cardiovascular system, two NO-sensitive guanylyl cyclase (NO-GC) isoforms are responsible for NO-dependent cGMP generation. Here, the impact of the major NO-GC isoform, NO-GC1, on fibrosis development in the cardiovascular system was studied in NO-GC...

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Bibliographic Details
Main Authors: Kathrin Broekmans, Jan Giesen, Lukas Menges, Doris Koesling, Michael Russwurm
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cells
Subjects:
angiotensin
nitric oxide
guanylyl cyclase
cGMP
Online Access:https://www.mdpi.com/2073-4409/9/11/2436

Internet

https://www.mdpi.com/2073-4409/9/11/2436

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