Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform

Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform

Snakebite envenoming is a neglected tropical disease that causes as many as 1.8 million envenomings and 140,000 deaths annually. To address treatment limitations that exist with current antivenoms, the search for small molecule drug-based inhibitors that can be administered as early interventions ha...

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Bibliographic Details
Main Authors: Laura-Oana Albulescu, Adam Westhorpe, Rachel H. Clare, Christopher M. Woodley, Nivya James, Jeroen Kool, Neil G. Berry, Paul M. O’Neill, Nicholas R. Casewell
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Pharmacology
Subjects:
high-throughput screening
drug discovery
toxin inhibitors
snake venom
snakebite envenoming
neglected tropical disease
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1331224/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1331224/full

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